I needed a 'commuting' vehicle and the Monster 620 fit the bill for me. I just passed 20,000 miles; ALL highway

(in 2 years)
The bike rides like a charm on the highway. Comfortable cruising speed is anywhere from 75 mph to 90 mph, with still enough umph to pass at 110 mph if required. Yes, there is some wind buffeting at higher speeds when behind large vehicles, but a non-issue at 75-85 mph. The previous post's comment about the lower seat is true; she may be more comfortable on this one. I believe that also the a newer model Monsters, 2004 onward, now have descent mirrors, and one can look passed the shoulders.
In all fairness, I have not yet ridden a Multistrada, but have never regretted my choice of the baby Duc.